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Structure paper

TitleCrystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 19, Page 754-759, Year 2012
Publish dateJun 29, 2012 (structure data deposition date)
AuthorsBandaranayake, R.M. / Ungureanu, D. / Shan, Y. / Shaw, D.E. / Silvennoinen, O. / Hubbard, S.R.
External linksNat. Struct. Mol. Biol. / PubMed:22820988
MethodsX-ray diffraction
Resolution1.75 - 2.01 Å
Structure data

PDB-4fvp:
Crystal structure of the Jak2 pseudokinase domain (apo form)
Method: X-RAY DIFFRACTION / Resolution: 2.01 Å

PDB-4fvq:
Crystal structure of the Jak2 pseudokinase domain (Mg-ATP-bound form)
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-4fvr:
Crystal structure of the Jak2 pseudokinase domain mutant V617F (Mg-ATP-bound form)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-ACT:
ACETATE ION

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / JANUS PROTEIN KINASE / PSEUDOKINASE / ATP BINDING / PHOSPHORYLATION

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