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Structure paper

TitleMolecular basis of beta-amyloid oligomer recognition with a conformational antibody fragment.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 109, Page 12503-12508, Year 2012
Publish dateSep 8, 2011 (structure data deposition date)
AuthorsMorgado, I. / Wieligmann, K. / Bereza, M. / Ronicke, R. / Meinhardt, K. / Annamalai, K. / Baumann, M. / Wacker, J. / Hortschansky, P. / Malesevic, M. ...Morgado, I. / Wieligmann, K. / Bereza, M. / Ronicke, R. / Meinhardt, K. / Annamalai, K. / Baumann, M. / Wacker, J. / Hortschansky, P. / Malesevic, M. / Parthier, C. / Mawrin, C. / Schiene-Fischer, C. / Reymann, K.G. / Stubbs, M.T. / Balbach, J. / Gorlach, M. / Horn, U. / Fandrich, M.
External linksProc. Natl. Acad. Sci. USA / PubMed:22814377
MethodsX-ray diffraction
Resolution1.3 Å
Structure data

PDB-3tpk:
Crystal structure of the oligomer-specific KW1 antibody fragment
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

Chemicals

ChemComp-BEN:
BENZAMIDINE

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • camelidae (mammal)
KeywordsIMMUNE SYSTEM / Immunoglobulin Heavy Chain Domains / VHH / Complementarity Determining Regions / CDR / oligomer-specific / Alzheimer's disease / Amyloid

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