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Structure paper

TitleCrystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc{varepsilon}RI.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 109, Page 12686-12691, Year 2012
Publish dateMay 3, 2012 (structure data deposition date)
AuthorsDhaliwal, B. / Yuan, D. / Pang, M.O. / Henry, A.J. / Cain, K. / Oxbrow, A. / Fabiane, S.M. / Beavil, A.J. / McDonnell, J.M. / Gould, H.J. / Sutton, B.J.
External linksProc. Natl. Acad. Sci. USA / PubMed:22802656
MethodsX-ray diffraction
Resolution3.1 Å
Structure data

PDB-4ezm:
Crystal structure of the human IgE-Fc(epsilon)3-4 bound to its B cell receptor derCD23
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-MAN:
alpha-D-mannopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Immunoglobulin fold Lectin / Antibody Receptor

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