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-Structure paper
| Title | Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors. |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 4967-4974, Year 2012 |
| Publish date | Jun 6, 2012 (structure data deposition date) |
 Authors | Peterson, E.A. / Boezio, A.A. / Andrews, P.S. / Boezio, C.M. / Bush, T.L. / Cheng, A.C. / Choquette, D. / Coats, J.R. / Colletti, A.E. / Copeland, K.W. ...Peterson, E.A. / Boezio, A.A. / Andrews, P.S. / Boezio, C.M. / Bush, T.L. / Cheng, A.C. / Choquette, D. / Coats, J.R. / Colletti, A.E. / Copeland, K.W. / Dupont, M. / Graceffa, R. / Grubinska, B. / Kim, J.L. / Lewis, R.T. / Liu, J. / Mullady, E.L. / Potashman, M.H. / Romero, K. / Shaffer, P.L. / Stanton, M.K. / Stellwagen, J.C. / Teffera, Y. / Yi, S. / Cai, T. / La, D.S. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:22765895 |
| Methods | X-ray diffraction |
| Resolution | 2.6 - 3 Å |
| Structure data |  PDB-4fhj:  PDB-4fhk: |
| Chemicals |  ChemComp-SO4:  ChemComp-0TZ:  ChemComp-HOH:  ChemComp-0U0: |
| Source |
|
 Keywords | Transferase/Inhibitor / inhibitor / p110 / kinase / transferase / ATP-binding / p84 / p101 / Transferase-Inhibitor complex / Transferase/Transferase Inhibitor / Transferase-Transferase Inhibitor complex |
homo sapiens (human)