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-Structure paper
Title | Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation. |
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Journal, issue, pages | Nucleic Acids Res., Vol. 40, Page 8276-8284, Year 2012 |
Publish date | Apr 26, 2012 (structure data deposition date) |
![]() | Hashimoto, H. / Zhang, X. / Cheng, X. |
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Methods | X-ray diffraction |
Resolution | 2.39 - 2.791 Å |
Structure data | ![]() PDB-4evv: ![]() PDB-4ew0: ![]() PDB-4ew4: |
Chemicals | ![]() ChemComp-EDO: ![]() ChemComp-NI: ![]() ChemComp-HOH: ![]() ChemComp-UNX: |
Source |
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![]() | HYDROLASE/DNA / G:T mismatch / deamination of cytosine / active DNA demethylation / Helix-hairpin-Helix / DNA glycosylases / HYDROLASE-DNA complex / 5-hydroxymethyluracil / deamination / 5-methylcytosine / DNA glycosylase / stable intermediate / N-glycosidic bond |