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Structure paper

TitleCyclic di-GMP Sensing via the Innate Immune Signaling Protein STING.
Journal, issue, pagesMol. Cell, Vol. 46, Page 735-745, Year 2012
Publish dateMay 18, 2012 (structure data deposition date)
AuthorsYin, Q. / Tian, Y. / Kabaleeswaran, V. / Jiang, X. / Tu, D. / Eck, M.J. / Chen, Z.J. / Wu, H.
External linksMol. Cell / PubMed:22705373
MethodsX-ray diffraction
Resolution2.75 - 2.95 Å
Structure data

PDB-4f9e:
Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-4f9g:
Crystal structure of STING complex with Cyclic di-GMP.
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-C2E:
9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / STING / ERIS / MITA / Stimulator of interferon genes protein / innate immunity 5helix and 5 beta strand / INTERFERON / IMMUNE SYSTEM C-DI-GMP Dimerisation

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