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TitleDissociation of Antibacterial Activity and Aminoglycoside Ototoxicity in the 4-Monosubstituted 2-Deoxystreptamine Apramycin.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 109, Page 10984-, Year 2012
Publish dateApr 20, 2012 (structure data deposition date)
AuthorsMatt, T. / Ng, C.L. / Lang, K. / Sha, S.H. / Akbergenov, R. / Shcherbakov, D. / Meyer, M. / Duscha, S. / Xie, J. / Dubbaka, S.R. ...Matt, T. / Ng, C.L. / Lang, K. / Sha, S.H. / Akbergenov, R. / Shcherbakov, D. / Meyer, M. / Duscha, S. / Xie, J. / Dubbaka, S.R. / Perez-Fernandez, D. / Vasella, A. / Ramakrishnan, V. / Schacht, J. / Bottger, E.C.
External linksProc. Natl. Acad. Sci. USA / PubMed:22699498
MethodsX-ray diffraction
Resolution3.5 Å
Structure data

PDB-4aqy:
Structure of ribosome-apramycin complexes
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-AM2:
APRAMYCIN / antibiotic*YM

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • thermus thermophilus (bacteria)
KeywordsRIBOSOME / APRAMYCIN / TOXICITY

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