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Structure paper

TitleAn Ultrahigh Affinity d-Peptide Antagonist Of MDM2.
Journal, issue, pagesJ. Med. Chem., Vol. 55, Page 6237-6241, Year 2012
Publish dateSep 8, 2011 (structure data deposition date)
AuthorsZhan, C. / Zhao, L. / Wei, X. / Wu, X. / Chen, X. / Yuan, W. / Lu, W.Y. / Pazgier, M. / Lu, W.
External linksJ. Med. Chem. / PubMed:22694121
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-3tpx:
Crystal structure of human MDM2 in complex with a trifluoromethylated D-peptide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE/LIGASE INHIBITOR / LIGASE-LIGASE INHIBITOR complex / MDM2-D-peptide inhibitor complex / p53-binding domain of MDM2-D-peptide inhibitor complex

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