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Structure paper

TitleTafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 109, Page 9629-9634, Year 2012
Publish dateAug 9, 2011 (structure data deposition date)
AuthorsBulawa, C.E. / Connelly, S. / Devit, M. / Wang, L. / Weigel, C. / Fleming, J.A. / Packman, J. / Powers, E.T. / Wiseman, R.L. / Foss, T.R. ...Bulawa, C.E. / Connelly, S. / Devit, M. / Wang, L. / Weigel, C. / Fleming, J.A. / Packman, J. / Powers, E.T. / Wiseman, R.L. / Foss, T.R. / Wilson, I.A. / Kelly, J.W. / Labaudiniere, R.
External linksProc. Natl. Acad. Sci. USA / PubMed:22645360
MethodsX-ray diffraction
Resolution1.3 Å
Structure data

PDB-3tct:
Structure of wild-type TTR in complex with tafamidis
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

Chemicals

ChemComp-3MI:
2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid / medication*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHORMONE / BINDING PROTEIN / AMYLOID / AMYLOIDOSIS / DISEASE MUTATION / GAMMA-CARBOXYGLUTAMIC ACID / GLYCOPROTEIN / NEUROPATHY / SECRETED / THYROID HORMONE / TRANSPORT / Kinetic Stabilizer / Inhibition of the Amyloid Cascade

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