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Structure paper

TitleStructure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.
Journal, issue, pagesBiochemistry, Vol. 51, Page 5083-5090, Year 2012
Publish dateJun 30, 2011 (structure data deposition date)
AuthorsFroese, D.S. / Krojer, T. / Wu, X. / Shrestha, R. / Kiyani, W. / von Delft, F. / Gravel, R.A. / Oppermann, U. / Yue, W.W.
External linksBiochemistry / PubMed:22642810
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-3som:
crystal structure of human MMACHC
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-B12:
COBALAMIN

ChemComp-FLC:
CITRATE ANION

ChemComp-DHL:
2-AMINO-ETHANETHIOL

ChemComp-5AD:
5'-DEOXYADENOSINE

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Structural Genomics / Structural Genomics Consortium / SGC / CblC / Organic aciduria / inborn errors of metabolism / cobalamin / vitamin B12 / cobalt(III)

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