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TitleRevealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells.
Journal, issue, pagesBiochem. J., Vol. 446, Page 79-87, Year 2012
Publish dateFeb 16, 2012 (structure data deposition date)
AuthorsWang, S. / Wang, Z. / Lin, S. / Zheng, W. / Wang, R. / Jin, S. / Chen, J. / Jin, L. / Li, Y.
External linksBiochem. J. / PubMed:22642567
MethodsX-ray diffraction
Resolution2.75 Å
Structure data

PDB-4dqm:
Revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-LUF:
(5S)-4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,7-dien-1-yl]-5-hydroxyfuran-2(5H)-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION/TRANSFERASE / nuclear receptor transcription factor / ligand binding domain / Transcription regulation / Nucleus / TRANSCRIPTION-TRANSFERASE complex

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