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TitleStructure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Journal, issue, pagesChem. Commun. (Camb. ), Vol. 48, Page 8195-8197, Year 2012
Publish dateNov 9, 2011 (structure data deposition date)
AuthorsPallan, P.S. / Allerson, C.R. / Berdeja, A. / Seth, P.P. / Swayze, E.E. / Prakash, T.P. / Egli, M.
External linksChem. Commun. (Camb. ) / PubMed:22614180
MethodsX-ray diffraction
Resolution1.42 - 1.68 Å
Structure data

PDB-3ukb:
(R)-cEt-BNA decamer structure
Method: X-RAY DIFFRACTION / Resolution: 1.42 Å

PDB-3ukc:
(S)-cEt-BNA decamer structure
Method: X-RAY DIFFRACTION / Resolution: 1.54 Å

PDB-3uke:
(S)-cMOE-BNA decamer structure
Method: X-RAY DIFFRACTION / Resolution: 1.68 Å

Chemicals

ChemComp-HOH:
WATER

KeywordsDNA / A-FORM DNA / BICYCLIC NUCLEIC ACID / BNA / cEt-BNA / ANTISENSE OLIGONUCLEOTIDES / c-MOE-BNA

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