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TitleStructure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 22, Page 4033-4037, Year 2012
Publish dateJan 27, 2012 (structure data deposition date)
AuthorsLe Brazidec, J.Y. / Pasis, A. / Tam, B. / Boykin, C. / Wang, D. / Marcotte, D.J. / Claassen, G. / Chong, J.H. / Chao, J. / Fan, J. ...Le Brazidec, J.Y. / Pasis, A. / Tam, B. / Boykin, C. / Wang, D. / Marcotte, D.J. / Claassen, G. / Chong, J.H. / Chao, J. / Fan, J. / Nguyen, K. / Silvian, L. / Ling, L. / Zhang, L. / Choi, M. / Teng, M. / Pathan, N. / Zhao, S. / Li, T. / Taveras, A.
External linksBioorg. Med. Chem. Lett. / PubMed:22607669
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-4dhf:
Structure of Aurora A mutant bound to Biogenidec cpd 15
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-0K6:
7-cyclopentyl-2-({1-methyl-5-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-3-yl}amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

ChemComp-PO4:
PHOSPHATE ION

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
Keywordstransferase/transferase inhibitor / Ser/Thr kinase mitotic kinase pyrazolopyrimidine / phosphorylation / TPX2 / transferase-transferase inhibitor complex

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