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Structure paper

TitleStructure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.
Journal, issue, pagesNature, Vol. 485, Page 395-399, Year 2012
Publish dateMar 22, 2012 (structure data deposition date)
AuthorsThompson, A.A. / Liu, W. / Chun, E. / Katritch, V. / Wu, H. / Vardy, E. / Huang, X.P. / Trapella, C. / Guerrini, R. / Calo, G. ...Thompson, A.A. / Liu, W. / Chun, E. / Katritch, V. / Wu, H. / Vardy, E. / Huang, X.P. / Trapella, C. / Guerrini, R. / Calo, G. / Roth, B.L. / Cherezov, V. / Stevens, R.C.
External linksNature / PubMed:22596163
MethodsX-ray diffraction
Resolution3.013 Å
Structure data

PDB-4ea3:
Structure of the N/OFQ Opioid Receptor in Complex with a Peptide Mimetic
Method: X-RAY DIFFRACTION / Resolution: 3.013 Å

Chemicals

ChemComp-0NN:
1-benzyl-N-[3-(1'H,3H-spiro[2-benzofuran-1,4'-piperidin]-1'-yl)propyl]-D-prolinamide

ChemComp-OLB:
(2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate

ChemComp-OLA:
OLEIC ACID

ChemComp-OLC:
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / PSI-biology GPCR network / Structural Genomics / GPCR membrane protein 7TM NOP ORL1 cytochrome b562 / receptor / nociceptin orphanin FQ compound 24 opioid / fusion / membrane transmembrane

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