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TitleA Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-A]Pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of Cep-33779.
Journal, issue, pagesJ. Med. Chem., Vol. 55, Page 5243-, Year 2012
Publish dateApr 16, 2012 (structure data deposition date)
AuthorsDugan, B.J. / Gingrich, D.E. / Mesaros, E.F. / Milkiewicz, K.L. / Curry, M.A. / Zulli, A.L. / Dobrzanski, P. / Serdikoff, C. / Jan, M. / Angeles, T.S. ...Dugan, B.J. / Gingrich, D.E. / Mesaros, E.F. / Milkiewicz, K.L. / Curry, M.A. / Zulli, A.L. / Dobrzanski, P. / Serdikoff, C. / Jan, M. / Angeles, T.S. / Albom, M.S. / Mason, J.L. / Aimone, L.D. / Meyer, S.L. / Huang, Z. / Wells-Knecht, K.J. / Ator, M.A. / Ruggeri, B.A. / Dorsey, B.D.
External linksJ. Med. Chem. / PubMed:22594690
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-4aqc:
Triazolopyridine-based Inhibitor of Janus Kinase 2
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-88A:
8-(4-methylsulfonylphenyl)-N-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / ATP-BINDING

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