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Structure paper

TitleGQ-16, a novel peroxisome proliferator-activated receptor (PPAR gamma) ligand, promotes insulin sensitization without weight gain.
Journal, issue, pagesJ. Biol. Chem., Vol. 287, Page 28169-28179, Year 2012
Publish dateJul 19, 2011 (structure data deposition date)
AuthorsAmato, A.A. / Rajagopalan, S. / Lin, J.Z. / Carvalho, B.M. / Figueira, A.C. / Lu, J. / Ayers, S.D. / Mottin, M. / Silveira, R.L. / Souza, P.C. ...Amato, A.A. / Rajagopalan, S. / Lin, J.Z. / Carvalho, B.M. / Figueira, A.C. / Lu, J. / Ayers, S.D. / Mottin, M. / Silveira, R.L. / Souza, P.C. / Mourao, R.H. / Saad, M.J. / Togashi, M. / Simeoni, L.A. / Abdalla, D.S. / Skaf, M.S. / Polikparpov, I. / Lima, M.C. / Galdino, S.L. / Brennan, R.G. / Baxter, J.D. / Pitta, I.R. / Webb, P. / Phillips, K.J. / Neves, F.A.
External linksJ. Biol. Chem. / PubMed:22584573
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-3t03:
Crystal structure of PPAR gamma ligand binding domain in complex with a novel partial agonist GQ-16
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-3T0:
(5Z)-5-(5-bromo-2-methoxybenzylidene)-3-(4-methylbenzyl)-1,3-thiazolidine-2,4-dione

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION/TRANSCRIPTION REGULATOR / Protein-Drug Complex / THIAZOLIDINEDIONES / Ligand Binding Protein / Transcription factor / Nucleus Receptor / TRANSCRIPTION-TRANSCRIPTION REGULATOR complex

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