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TitleThe mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1.
Journal, issue, pagesBiochim. Biophys. Acta, Vol. 1824, Page 938-945, Year 2012
Publish dateApr 30, 2012 (structure data deposition date)
AuthorsLiu, H. / Leo, C. / Chen, X. / Wong, B.R. / Williams, L.T. / Lin, H. / He, X.
External linksBiochim. Biophys. Acta / PubMed:22579672
MethodsX-ray diffraction
Resolution2.7 - 2.8 Å
Structure data

PDB-4exn:
Crystal structure of mouse Interleukin-34
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-4exp:
Structure of mouse Interleukin-34 in complex with mouse FMS
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • mus musculus (house mouse)
KeywordsCYTOKINE / extended 4-helix bundle / c-FMS / CSF-1R / CYTOKINE/TRANSFERASE / immunoglobunin / beta-sandwich / CYTOKINE-TRANSFERASE complex

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