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Structure paper

TitleLateral Clustering of TLR3:dsRNA Signaling Units Revealed by TLR3ecd:3Fabs Quaternary Structure.
Journal, issue, pagesJ. Mol. Biol., Vol. 421, Page 112-124, Year 2012
Publish dateNov 11, 2011 (structure data deposition date)
AuthorsLuo, J. / Obmolova, G. / Malia, T.J. / Wu, S.J. / Duffy, K.E. / Marion, J.D. / Bell, J.K. / Ge, P. / Zhou, Z.H. / Teplyakov, A. ...Luo, J. / Obmolova, G. / Malia, T.J. / Wu, S.J. / Duffy, K.E. / Marion, J.D. / Bell, J.K. / Ge, P. / Zhou, Z.H. / Teplyakov, A. / Zhao, Y. / Lamb, R.J. / Jordan, J.L. / San Mateo, L.R. / Sweet, R.W. / Gilliland, G.L.
External linksJ. Mol. Biol. / PubMed:22579623
MethodsX-ray diffraction
Resolution2.495 - 3.522 Å
Structure data

PDB-3uls:
Crystal structure of Fab12
Method: X-RAY DIFFRACTION / Resolution: 2.495 Å

PDB-3ulu:
Structure of quaternary complex of human TLR3ecd with three Fabs (Form1)
Method: X-RAY DIFFRACTION / Resolution: 3.52 Å

PDB-3ulv:
Structure of quaternary complex of human TLR3ecd with three Fabs (Form2)
Method: X-RAY DIFFRACTION / Resolution: 3.522 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Toll-like receptor-3 / TLR3 / innate immunity / immunoglobulin / leucine rich repeat / LRR

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