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-Structure paper
Title | Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil. |
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Journal, issue, pages | Antimicrob. Agents Chemother., Vol. 56, Page 3928-3935, Year 2012 |
Publish date | Nov 12, 2011 (structure data deposition date) |
Authors | Vanichtanankul, J. / Taweechai, S. / Uttamapinant, C. / Chitnumsub, P. / Vilaivan, T. / Yuthavong, Y. / Kamchonwongpaisan, S. |
External links | Antimicrob. Agents Chemother. / PubMed:22526319 |
Methods | X-ray diffraction |
Resolution | 2.4 - 2.65 Å |
Structure data | PDB-3um5: PDB-3um6: PDB-3um8: |
Chemicals | ChemComp-CP6: ChemComp-NDP: ChemComp-UMP: ChemComp-HOH: ChemComp-1CY: ChemComp-PO4: |
Source |
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Keywords | OXIDOREDUCTASE / TRANSFERASE/INHIBITOR / MALARIAL DHFR-TS / PYRIMETHAMINE / ANTIFOLATE / NAPDH / DUMP / TRANSFERASE-INHIBITOR COMPLEX / CYCLOGUANIL / NADPH |