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| Title | Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective Pi3Kbeta Inhibitors for the Treatment of Phosphatase and Tensin Homologue (Pten)-Deficient Cancers. |
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| Journal, issue, pages | J. Med. Chem., Vol. 55, Page 4788-, Year 2012 |
| Publish date | Feb 20, 2012 (structure data deposition date) |
 Authors | Certal, V. / Halley, F. / Virone-Oddos, A. / Delorme, C. / Karlsson, A. / Rak, A. / Thompson, F. / Filoche-Romm, B. / El-Ahmad, Y. / Carry, J.C. ...Certal, V. / Halley, F. / Virone-Oddos, A. / Delorme, C. / Karlsson, A. / Rak, A. / Thompson, F. / Filoche-Romm, B. / El-Ahmad, Y. / Carry, J.C. / Abecassis, P.Y. / Lejeune, P. / Vincent, L. / Bonnevaux, H. / Nicolas, J.P. / Bertrand, T. / Marquette, J.P. / Michot, N. / Benard, T. / Below, P. / Vade, I. / Chatreaux, F. / Lebourg, G. / Pilorge, F. / Angouillant-Boniface, O. / Louboutin, A. / Lengauer, C. / Schio, L. |
 External links | J. Med. Chem. / PubMed:22524426 |
| Methods | X-ray diffraction |
| Resolution | 2.8 Å |
| Structure data |  PDB-4ajw: |
| Chemicals |  ChemComp-VWN:  ChemComp-HOH: |
| Source |
|
 Keywords | TRANSFERASE / P110D |
mus musculus (house mouse)