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TitleConversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.
Journal, issue, pagesFaseb J., Vol. 26, Page 3222-3229, Year 2012
Publish dateDec 23, 2011 (structure data deposition date)
AuthorsGilbert, N.C. / Rui, Z. / Neau, D.B. / Waight, M.T. / Bartlett, S.G. / Boeglin, W.E. / Brash, A.R. / Newcomer, M.E.
External linksFaseb J. / PubMed:22516296
MethodsX-ray diffraction
Resolution2.07 - 2.74 Å
Structure data

PDB-3v92:
S663A Stable-5-LOX
Method: X-RAY DIFFRACTION / Resolution: 2.74 Å

PDB-3v98:
S663D Stable-5-LOX
Method: X-RAY DIFFRACTION / Resolution: 2.07 Å

PDB-3v99:
S663D Stable-5-LOX in complex with Arachidonic Acid
Method: X-RAY DIFFRACTION / Resolution: 2.252 Å

Chemicals

ChemComp-FE2:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-ACD:
ARACHIDONIC ACID

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Lipoxygenase / dioxygenase

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