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-Structure paper
Title | Design of substituted bis-Tetrahydrofuran (bis-THF)-derived Potent HIV-1 Protease Inhibitors, Protein-ligand X-ray Structure, and Convenient Syntheses of bis-THF and Substituted bis-THF Ligands. |
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Journal, issue, pages | ACS Med Chem Lett, Vol. 2, Page 298-302, Year 2011 |
Publish date | Jan 10, 2011 (structure data deposition date) |
Authors | Ghosh, A.K. / Martyr, C.D. / Steffey, M. / Wang, Y.F. / Agniswamy, J. / Amano, M. / Weber, I.T. / Mitsuya, H. |
External links | PubMed:22509432 |
Methods | X-ray diffraction |
Resolution | 1.4 Å |
Structure data | PDB-3qaa: |
Chemicals | ChemComp-G04: ChemComp-NA: ChemComp-CL: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / aspartic acid protease / HIV-1 protease inhibitor GRL-044-10A / substituted bis-tetrahydrofuran inhibitor / wild-type HIV-1 protease / HYDROLASE-HYDROLASE INHIBITOR complex |