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TitleHydroxamic Acids as Potent Inhibitors of Fe(II) and Mn(II) E. Coli Methionine Aminopeptidase: Biological Activities and X-Ray Structures of Oxazole Hydroxamate-Ecmetap-Mn Complexes.
Journal, issue, pagesChemmedchem, Vol. 7, Page 1020-, Year 2012
Publish dateNov 9, 2011 (structure data deposition date)
AuthorsHuguet, F. / Melet, A. / Alves De Sousa, R. / Lieutaud, A. / Chevalier, J. / Maigre, L. / Deschamps, P. / Tomas, A. / Leulliot, N. / Pages, J.M. / Artaud, I.
External linksChemmedchem / PubMed:22489069
MethodsX-ray diffraction
Resolution1.46 Å
Structure data

PDB-4a6v:
X-ray structures of oxazole hydroxamate EcMetAp-Mn complexes
Method: X-RAY DIFFRACTION / Resolution: 1.46 Å

PDB-4a6w:
X-ray structures of oxazole hydroxamate EcMetAp-Mn complexes
Method: X-RAY DIFFRACTION / Resolution: 1.46 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-CO3:
CARBONATE ION

ChemComp-IKY:
N-HYDROXY-2-[2-(TRIFLUOROMETHYL)PHENYL]-1,3-OXAZOLE-4-CARBOXAMIDE

ChemComp-HOH:
WATER

ChemComp-5C1:
5-(2-chlorophenyl)-N-hydroxy-1,3-oxazole-2-carboxamide

Source
  • escherichia coli (E. coli)
KeywordsHYDROLASE / TRANSFERASE

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