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Structure paper

TitleStructural basis for high selectivity of anti-CCL2 neutralizing antibody CNTO 888.
Journal, issue, pagesMol. Immunol., Vol. 51, Page 227-233, Year 2012
Publish dateFeb 8, 2012 (structure data deposition date)
AuthorsObmolova, G. / Teplyakov, A. / Malia, T.J. / Grygiel, T.L. / Sweet, R. / Snyder, L.A. / Gilliland, G.L.
External linksMol. Immunol. / PubMed:22487721
MethodsX-ray diffraction
Resolution2.6 - 2.8 Å
Structure data

PDB-4dn3:
Crystal structure of anti-mcp-1 antibody cnto888
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-4dn4:
Crystal structure of the complex between cnto888 fab and mcp-1 mutant p8a
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-ACT:
ACETATE ION

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / antibody / antibody chemokine

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