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Title | Design of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New Scaffold. |
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Journal, issue, pages | J. Med. Chem., Vol. 55, Page 4664-4682, Year 2012 |
Publish date | Jul 1, 2011 (structure data deposition date) |
![]() | Zhou, H. / Chen, J. / Meagher, J.L. / Yang, C.Y. / Aguilar, A. / Liu, L. / Bai, L. / Cong, X. / Cai, Q. / Fang, X. ...Zhou, H. / Chen, J. / Meagher, J.L. / Yang, C.Y. / Aguilar, A. / Liu, L. / Bai, L. / Cong, X. / Cai, Q. / Fang, X. / Stuckey, J.A. / Wang, S. |
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Methods | X-ray diffraction |
Resolution | 1.7 Å |
Structure data | ![]() PDB-3spf: |
Chemicals | ![]() ChemComp-B50: ![]() ChemComp-GOL: ![]() ChemComp-HOH: |
Source |
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![]() | APOPTOSIS REGULATOR/INHIBITOR / Bcl-2-like protein / APOPTOSIS-APOPTOSIS INHIBITOR complex / APOPTOSIS REGULATOR-INHIBITOR complex |