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TitleComparative Active-Site Mutation Study of Human and Caenorhabditis Elegans Thymidine Kinase 1.
Journal, issue, pagesFEBS J., Vol. 279, Page 1777-, Year 2012
Publish dateOct 17, 2009 (structure data deposition date)
AuthorsSkovgaard, T. / Uhlin, U. / Munch-Petersen, B.
External linksFEBS J. / PubMed:22385435
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-2wvj:
Mutation of Thr163 to Ser in Human Thymidine Kinase Shifts the Specificity from Thymidine towards the Nucleoside Analogue Azidothymidine
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-TTP:
THYMIDINE-5'-TRIPHOSPHATE

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / ZINC-BINDING DOMAIN / DEOXYRIBONUCLEOSIDE KINASE / FEEDBACK INHIBITOR / NUCLEOTIDE-BINDING / KINASE / CYTOPLASM / ATP-BINDING / DNA SYNTHESIS / PHOSPHOPROTEIN / PHOSPHORYLATION

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