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Structure paper

TitleAminoglycoside-2' phosphotransferase-IIIa (APH(2')-IIIa) prefers GTP over ATP: Structural templates for nucleotide recognition in the bacterial aminoglycoside-2' kinases.
Journal, issue, pagesJ. Biol. Chem., Vol. 287, Page 12893-12903, Year 2012
Publish dateAug 11, 2011 (structure data deposition date)
AuthorsSmith, C.A. / Toth, M. / Frase, H. / Byrnes, L.J. / Vakulenko, S.B.
External linksJ. Biol. Chem. / PubMed:22367198
MethodsX-ray diffraction
Resolution1.7 - 2.2 Å
Structure data

PDB-3tdv:
Structure of the GDP complex of wild-type aminoglycoside 2'-phosphotransferase-IIIa
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-3tdw:
The GDP complex of the aminoglycoside 2'-phosphotransfere-IIIa F108L mutant
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • enterococcus gallinarum (bacteria)
KeywordsTRANSFERASE / kinase / phosphoryl transfer / antibiotic resistance / gentamicin

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