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-Structure paper
Title | Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 2262-2265, Year 2012 |
Publish date | Jan 18, 2012 (structure data deposition date) |
Authors | Hu, E. / Kunz, R.K. / Rumfelt, S. / Chen, N. / Burli, R. / Li, C. / Andrews, K.L. / Zhang, J. / Chmait, S. / Kogan, J. ...Hu, E. / Kunz, R.K. / Rumfelt, S. / Chen, N. / Burli, R. / Li, C. / Andrews, K.L. / Zhang, J. / Chmait, S. / Kogan, J. / Lindstrom, M. / Hitchcock, S.A. / Treanor, J. |
External links | Bioorg. Med. Chem. Lett. / PubMed:22365755 |
Methods | X-ray diffraction |
Resolution | 2.07 Å |
Structure data | PDB-4ddl: |
Chemicals | ChemComp-ZN: ChemComp-SO4: ChemComp-0JQ: ChemComp-HOH: |
Source |
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Keywords | Hydrolase/Hydrolase Inhibitor / Phosphodiesterase 10a / Hydrolase / Hydrolase-Hydrolase Inhibitor complex |