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-Structure paper
Title | Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 2308-2311, Year 2012 |
Publish date | Jan 23, 2012 (structure data deposition date) |
![]() | Ghosh, A.K. / Chapsal, B.D. / Steffey, M. / Agniswamy, J. / Wang, Y.F. / Amano, M. / Weber, I.T. / Mitsuya, H. |
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Methods | X-ray diffraction |
Resolution | 1.23 Å |
Structure data | ![]() PDB-4dfg: |
Chemicals | ![]() ChemComp-NA: ![]() ChemComp-CL: ![]() ChemComp-0JV: ![]() ChemComp-HOH: |
Source |
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![]() | hydrolase/hydrolase inhibitor / aspartic acid protease / HIV-1 protease inhibitor GRL-0249A / Cyclopentyltetrahydro- furanyl Urethanes P2-ligands / wild-type HIV-1 protease / hydrolase-hydrolase inhibitor complex |