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TitleReplication bypass of the trans-4-Hydroxynonenal-derived (6S,8R,11S)-1,N(2)-deoxyguanosine DNA adduct by the sulfolobus solfataricus DNA polymerase IV.
Journal, issue, pagesChem. Res. Toxicol., Vol. 25, Page 422-435, Year 2012
Publish dateJul 27, 2011 (structure data deposition date)
AuthorsBanerjee, S. / Christov, P.P. / Kozekova, A. / Rizzo, C.J. / Egli, M. / Stone, M.P.
External linksChem. Res. Toxicol. / PubMed:22313351
MethodsX-ray diffraction
Resolution2.35 - 2.9 Å
Structure data

PDB-3t5h:
Ternary complex of HNE Adduct modified DNA (5'-CXG-3' vs 13-mer) with Dpo4 and incoming dDGT
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-3t5j:
Ternary complex of HNE Adduct modified DNA (5'-TXG-3' vs 13-mer) with Dpo4 and incoming dDTP
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3t5k:
Ternary complex of HNE Adduct modified DNA (5'-TXG-3' vs 14-mer) with Dpo4 and incoming dDTP
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-3t5l:
Ternary complex of HNE Adduct modified DNA (5'-CXG-3' vs 14-mer) with Dpo4 and incoming dDGT
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-DGT:
2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-DTP:
2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

Source
  • sulfolobus solfataricus p2 (archaea)
KeywordsDNA/Transferase / Ternary complex of Dpo4-DNA-dGTP / DNA Polymerase / HNE / DNA-Transferase complex / Ternary complex of Dpo4-DNA-dATP

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