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-Structure paper
Title | A beta-tryptase inhibitor with a tropanylamide scaffold to improve in vitro stability and to lower hERG channel binding affinity |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 1606-1610, Year 2012 |
Publish date | Dec 22, 2011 (structure data deposition date) |
Authors | Liang, G. / Choi-Sledeski, Y.M. / Shum, P. / Chen, X. / Poli, G.B. / Kumar, V. / Minnich, A. / Wang, Q. / Tsay, J. / Sides, K. ...Liang, G. / Choi-Sledeski, Y.M. / Shum, P. / Chen, X. / Poli, G.B. / Kumar, V. / Minnich, A. / Wang, Q. / Tsay, J. / Sides, K. / Kang, J. / Zhang, Y. |
External links | Bioorg. Med. Chem. Lett. / PubMed:22264487 |
Methods | X-ray diffraction |
Resolution | 2.09 Å |
Structure data | PDB-3v7t: |
Chemicals | ChemComp-0GX: ChemComp-CO3: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / tryptase / serine protease / tetramer / protein-ligand complex / HYDROLASE-HYDROLASE INHIBITOR complex |