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TitleRapid development of piperidine carboxamides as potent and selective anaplastic lymphoma kinase inhibitors.
Journal, issue, pagesJ. Med. Chem., Vol. 55, Page 1698-1705, Year 2012
Publish dateJan 17, 2012 (structure data deposition date)
AuthorsBryan, M.C. / Whittington, D.A. / Doherty, E.M. / Falsey, J.R. / Cheng, A.C. / Emkey, R. / Brake, R.L. / Lewis, R.T.
External linksJ. Med. Chem. / PubMed:22263917
MethodsX-ray diffraction
Resolution2.03 Å
Structure data

PDB-4dce:
Crystal structure of human anaplastic lymphoma kinase in complex with a piperidine-carboxamide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

Chemicals

ChemComp-0JF:
(3S)-N-(4-methylbenzyl)-1-{2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}piperidine-3-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTransferase/Inhibitor / receptor tyrosine kinase / inhibitor / NPM-ALK / EML4-ALK / Transferase-Inhibitor complex

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