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Structure paper

TitleStructure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.
Journal, issue, pagesBiochemistry, Vol. 29, Page 6964-6977, Year 1990
Publish dateJul 3, 1991 (structure data deposition date)
AuthorsMontfort, W.R. / Perry, K.M. / Fauman, E.B. / Finer-Moore, J.S. / Maley, G.F. / Hardy, L. / Maley, F. / Stroud, R.M.
External linksBiochemistry / PubMed:2223754
MethodsX-ray diffraction
Resolution1.97 Å
Structure data

PDB-2tsc:
STRUCTURE, MULTIPLE SITE BINDING, AND SEGMENTAL ACCOMODATION IN THYMIDYLATE SYNTHASE ON BINDING D/UMP AND AN ANTI-FOLATE
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

Chemicals

ChemComp-UMP:
2'-DEOXYURIDINE 5'-MONOPHOSPHATE

ChemComp-CB3:
10-PROPARGYL-5,8-DIDEAZAFOLIC ACID

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsTRANSFERASE (METHYLTRANSFERASE)

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