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Structure paper

TitleThe discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 22, Page 1019-1022, Year 2012
Publish dateNov 28, 2011 (structure data deposition date)
AuthorsHo, G.D. / Yang, S.W. / Smotryski, J. / Bercovici, A. / Nechuta, T. / Smith, E.M. / McElroy, W. / Tan, Z. / Tulshian, D. / McKittrick, B. ...Ho, G.D. / Yang, S.W. / Smotryski, J. / Bercovici, A. / Nechuta, T. / Smith, E.M. / McElroy, W. / Tan, Z. / Tulshian, D. / McKittrick, B. / Greenlee, W.J. / Hruza, A. / Xiao, L. / Rindgen, D. / Mullins, D. / Guzzi, M. / Zhang, X. / Bleickardt, C. / Hodgson, R.
External linksBioorg. Med. Chem. Lett. / PubMed:22222034
MethodsX-ray diffraction
Resolution2.11 Å
Structure data

PDB-3uuo:
The discovery of potent, selectivity, and orally bioavailable pyrozoloquinolines as PDE10 inhibitors for the treatment of Schizophrenia
Method: X-RAY DIFFRACTION / Resolution: 2.11 Å

Chemicals

ChemComp-0CV:
6-methoxy-3,8-dimethyl-4-(piperazin-1-yl)-1H-pyrazolo[3,4-b]quinoline

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / INHIBITOR COMPLEX / HYDROLASE / ZN BINDING / MG BINDING / HYDROLASE-HYDROLASE INHIBITOR complex

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