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Structure paper

TitleTeaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold.
Journal, issue, pagesJ. Mol. Biol., Vol. 415, Page 393-405, Year 2012
Publish dateMay 12, 2011 (structure data deposition date)
AuthorsKoide, A. / Wojcik, J. / Gilbreth, R.N. / Hoey, R.J. / Koide, S.
External linksJ. Mol. Biol. / PubMed:22198408
MethodsX-ray diffraction
Resolution1.83 - 2.15 Å
Structure data

PDB-3rzw:
Crystal Structure of the Monobody ySMB-9 bound to human SUMO1
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-3uyo:
Crystal structure of monobody SH13/ABL1 SH2 domain complex
Method: X-RAY DIFFRACTION / Resolution: 1.83 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / Beta Sandwich / Beta Grasp / Antibody mimic / Engineered Binding Protein / Post-translational Modification / SIGNALING PROTEIN/PROTEIN BINDING / protein-protein complex / SH2 domain / ATP-binding / phosphoprotein / tyrosine-protein kinase / signaling protein-protein binding complex

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