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Structure paper

TitleStructural and energetic evidence for highly peptide-specific tumor antigen targeting via allo-MHC restriction.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 108, Page 21176-21181, Year 2011
Publish dateApr 5, 2011 (structure data deposition date)
AuthorsSimpson, A.A. / Mohammed, F. / Salim, M. / Tranter, A. / Rickinson, A.B. / Stauss, H.J. / Moss, P.A. / Steven, N.M. / Willcox, B.E.
External linksProc. Natl. Acad. Sci. USA / PubMed:22160697
MethodsX-ray diffraction
Resolution1.9 - 2.2 Å
Structure data

PDB-3rev:
Crystal structure of human alloreactive tcr nb20
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-3rew:
Crystal structure of an lmp2a-derived peptide bound to human class i mhc hla-a2
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-IOD:
IODIDE ION

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
  • human herpesvirus 4 (strain b95-8) (Epstein-Barr virus (strain B95-8))
KeywordsIMMUNE SYSTEM / T CELL RECEPTOR / MHC CLASS I / TUMOUR ANTIGEN / IMMUNE RESPONSE / ALLOREACTIVITY / IMMUNOGLOBULIN DOMAIN / TUMOUR ANTIGEN TARGETING / HLA-A2 / EPSTEIN BARR VIRUS / GLYCOPROTEIN / MHC I

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