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Structure paper

TitleStructural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif
Journal, issue, pagesJ. Immunol., Vol. 188, Page 765-773, Year 2012
Publish dateAug 25, 2011 (structure data deposition date)
AuthorsWang, L. / Zhang, K. / Wu, L. / Liu, S. / Zhang, H. / Zhou, Q. / Tong, L. / Sun, F. / Fan, Z.
External linksJ. Immunol. / PubMed:22156497
MethodsX-ray diffraction
Resolution2.2 - 2.7 Å
Structure data

PDB-3tju:
Crystal structure of human granzyme H with an inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-3tjv:
Crystal structure of human granzyme H with a peptidyl substrate
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3tk9:
Crystal structure of human granzyme H
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / serine protease / Cytolysis / HYDROLASE-HYDROLASE INHIBITOR complex / HYDROLASE / HYDROLASE SUBSTRATE

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