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TitleRobust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor.
Journal, issue, pagesJ. Neurosci., Vol. 31, Page 16507-16516, Year 2011
Publish dateFeb 18, 2015 (structure data deposition date)
AuthorsMay, P.C. / Dean, R.A. / Lowe, S.L. / Martenyi, F. / Sheehan, S.M. / Boggs, L.N. / Monk, S.A. / Mathes, B.M. / Mergott, D.J. / Watson, B.M. ...May, P.C. / Dean, R.A. / Lowe, S.L. / Martenyi, F. / Sheehan, S.M. / Boggs, L.N. / Monk, S.A. / Mathes, B.M. / Mergott, D.J. / Watson, B.M. / Stout, S.L. / Timm, D.E. / Smith Labell, E. / Gonzales, C.R. / Nakano, M. / Jhee, S.S. / Yen, M. / Ereshefsky, L. / Lindstrom, T.D. / Calligaro, D.O. / Cocke, P.J. / Greg Hall, D. / Friedrich, S. / Citron, M. / Audia, J.E.
External linksJ. Neurosci. / PubMed:22090477
MethodsX-ray diffraction
Resolution1.84 Å
Structure data

PDB-4ybi:
Crystal structure of BACE with amino thiazine inhibitor LY2811376
Method: X-RAY DIFFRACTION / Resolution: 1.84 Å

Chemicals

ChemComp-4B2:
(4S)-4-[2,4-difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHydrolase/Hydrolase Inhibitor / inhibitor / complex / aspartyl / protease / beta-secretase / Hydrolase-Hydrolase Inhibitor complex

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