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-Structure paper
Title | Robust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor. |
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Journal, issue, pages | J. Neurosci., Vol. 31, Page 16507-16516, Year 2011 |
Publish date | Feb 18, 2015 (structure data deposition date) |
![]() | May, P.C. / Dean, R.A. / Lowe, S.L. / Martenyi, F. / Sheehan, S.M. / Boggs, L.N. / Monk, S.A. / Mathes, B.M. / Mergott, D.J. / Watson, B.M. ...May, P.C. / Dean, R.A. / Lowe, S.L. / Martenyi, F. / Sheehan, S.M. / Boggs, L.N. / Monk, S.A. / Mathes, B.M. / Mergott, D.J. / Watson, B.M. / Stout, S.L. / Timm, D.E. / Smith Labell, E. / Gonzales, C.R. / Nakano, M. / Jhee, S.S. / Yen, M. / Ereshefsky, L. / Lindstrom, T.D. / Calligaro, D.O. / Cocke, P.J. / Greg Hall, D. / Friedrich, S. / Citron, M. / Audia, J.E. |
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Methods | X-ray diffraction |
Resolution | 1.84 Å |
Structure data | ![]() PDB-4ybi: |
Chemicals | ![]() ChemComp-4B2: ![]() ChemComp-GOL: ![]() ChemComp-HOH: |
Source |
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![]() | Hydrolase/Hydrolase Inhibitor / inhibitor / complex / aspartyl / protease / beta-secretase / Hydrolase-Hydrolase Inhibitor complex |