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Structure paper

TitleEvaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 134, Page 315-, Year 2012
Publish dateSep 20, 2011 (structure data deposition date)
AuthorsBoersma, M.D. / Haase, H.S. / Peterson-Kaufman, K.J. / Lee, E.F. / Clarke, O.B. / Colman, P.M. / Smith, B.J. / Horne, W.S. / Fairlie, W.D. / Gellman, S.H.
External linksJ. Am. Chem. Soc. / PubMed:22040025
MethodsX-ray diffraction
Resolution1.54 - 2.497 Å
Structure data

PDB-4a1u:
Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL
Method: X-RAY DIFFRACTION / Resolution: 1.54 Å

PDB-4a1w:
Crystal structure of alpha-beta foldamer 4c in complex with Bcl-xL
Method: X-RAY DIFFRACTION / Resolution: 2.497 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsAPOPTOSIS / ALPHA-HELIX / BH3 / MIMICRY / APOPTOSIS/INHIBITOR / APOPTOSIS-INHIBITOR COMPLEX

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