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Structure paper

TitleCrystal Structure of the Epha4 Protein Tyrosine Kinase Domain in the Apo- and Dasatinib-Bound State.
Journal, issue, pagesFEBS Lett., Vol. 585, Page 3593-, Year 2011
Publish dateJan 25, 2011 (structure data deposition date)
AuthorsFarenc, C.J.A. / Hameetman, L. / Zoutman, W. / Tensen, C.P. / Siegal, G.
External linksFEBS Lett. / PubMed:22036717
MethodsX-ray diffraction
Resolution1.543 - 1.7 Å
Structure data

PDB-2y6m:
Crystal structure of EphA4 kinase domain
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-2y6o:
Crystal structure of EphA4 kinase domain in complex with Dasatinib.
Method: X-RAY DIFFRACTION / Resolution: 1.543 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-1N1:
N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE / medication*YM

Source
  • mus musculus (house mouse)
KeywordsTRANSFERASE / SIGNALLING PROTEIN

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