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TitleAntagonists induce a conformational change in cIAP1 that promotes autoubiquitination.
Journal, issue, pagesScience, Vol. 334, Page 376-380, Year 2011
Publish dateJul 28, 2011 (structure data deposition date)
AuthorsDueber, E.C. / Schoeffler, A.J. / Lingel, A. / Elliott, J.M. / Fedorova, A.V. / Giannetti, A.M. / Zobel, K. / Maurer, B. / Varfolomeev, E. / Wu, P. ...Dueber, E.C. / Schoeffler, A.J. / Lingel, A. / Elliott, J.M. / Fedorova, A.V. / Giannetti, A.M. / Zobel, K. / Maurer, B. / Varfolomeev, E. / Wu, P. / Wallweber, H.J. / Hymowitz, S.G. / Deshayes, K. / Vucic, D. / Fairbrother, W.J.
External linksScience / PubMed:22021857
MethodsX-ray diffraction
Resolution1.897 Å
Structure data

PDB-3t6p:
IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization
Method: X-RAY DIFFRACTION / Resolution: 1.897 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsAPOPTOSIS / RING / BIR / CARD / UBA / E3 / ubiquitin ligase / SMAC/DIABLO / ubiquitin / caspase / IAP family / SMAC mimetic

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