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TitleProprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates.
Journal, issue, pagesJ. Pharmacol. Exp. Ther., Vol. 340, Page 228-236, Year 2012
Publish dateJul 5, 2011 (structure data deposition date)
AuthorsLiang, H. / Chaparro-Riggers, J. / Strop, P. / Geng, T. / Sutton, J.E. / Tsai, D. / Bai, L. / Abdiche, Y. / Dilley, J. / Yu, J. ...Liang, H. / Chaparro-Riggers, J. / Strop, P. / Geng, T. / Sutton, J.E. / Tsai, D. / Bai, L. / Abdiche, Y. / Dilley, J. / Yu, J. / Wu, S. / Chin, S.M. / Lee, N.A. / Rossi, A. / Lin, J.C. / Rajpal, A. / Pons, J. / Shelton, D.L.
External linksJ. Pharmacol. Exp. Ther. / PubMed:22019884
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-3sqo:
PCSK9 J16 Fab complex
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/Immune system / cholesterol regulation / LDLR / HYDROLASE-Immune system complex

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