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TitleTargeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis.
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 147, Page 306-319, Year 2011
Publish dateJul 19, 2011 (structure data deposition date)
AuthorsGrebien, F. / Hantschel, O. / Wojcik, J. / Kaupe, I. / Kovacic, B. / Wyrzucki, A.M. / Gish, G.D. / Cerny-Reiterer, S. / Koide, A. / Beug, H. ...Grebien, F. / Hantschel, O. / Wojcik, J. / Kaupe, I. / Kovacic, B. / Wyrzucki, A.M. / Gish, G.D. / Cerny-Reiterer, S. / Koide, A. / Beug, H. / Pawson, T. / Valent, P. / Koide, S. / Superti-Furga, G.
External linksCell(Cambridge,Mass. ) / PubMed:22000011
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-3t04:
Crystal structure of monobody 7c12/abl1 sh2 domain complex
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN/PROTEIN BINDING / ENGINEERED BINDING PROTEIN / ANTIBODY MIMIC / PROTEIN-PROTEIN COMPLEX / SH2 DOMAIN / ATP-BINDING / PHOSPHOPROTEIN / TYROSINE-PROTEIN KINASE / SIGNALING PROTEIN-PROTEIN BINDING complex

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