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-Structure paper
Title | Design and synthesis of conformationally constrained inhibitors of non-nucleoside reverse transcriptase. |
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Journal, issue, pages | J. Med. Chem., Vol. 54, Page 7920-7933, Year 2011 |
Publish date | Jul 21, 2011 (structure data deposition date) |
Authors | Gomez, R. / Jolly, S.J. / Williams, T. / Vacca, J.P. / Torrent, M. / McGaughey, G. / Lai, M.T. / Felock, P. / Munshi, V. / Distefano, D. ...Gomez, R. / Jolly, S.J. / Williams, T. / Vacca, J.P. / Torrent, M. / McGaughey, G. / Lai, M.T. / Felock, P. / Munshi, V. / Distefano, D. / Flynn, J. / Miller, M. / Yan, Y. / Reid, J. / Sanchez, R. / Liang, Y. / Paton, B. / Wan, B.L. / Anthony, N. |
External links | J. Med. Chem. / PubMed:21985673 |
Methods | X-ray diffraction |
Resolution | 2.4 - 2.6 Å |
Structure data | PDB-3t19: PDB-3t1a: |
Chemicals | ChemComp-5MA: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / HIV-1 reverse transcriptase / non-nucleoside inhibition / nucleotidyltrasferase / HIV-1 / TRANSFERASE-TRANSFERASE INHIBITOR complex / nucleotidyltranferase / TRANSFERASE |