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Structure paper

TitleStructural Basis for Specificity of TGFbeta Family Receptor Small Molecule Inhibitors
Journal, issue, pagesCell Signal, Vol. 24, Page 476-483, Year 2012
Publish dateSep 27, 2011 (structure data deposition date)
AuthorsOgunjimi, A.A. / Zeqiraj, E. / Ceccarelli, D.F. / Sicheri, F. / Wrana, J.L. / David, L.
External linksCell Signal / PubMed:21983015
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-3tzm:
TGF-beta Receptor type 1 in complex with SB431542
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-085:
4-[5-(1,3-benzodioxol-5-yl)-4-(pyridin-2-yl)-1H-imidazol-2-yl]benzamide / inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / ALK5 / SB431542 / kinase domain / TRANSFERASE-TRANSFERASE INHIBITOR complex

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