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-Structure paper
Title | Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer. |
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Journal, issue, pages | J. Med. Chem., Vol. 54, Page 7579-7587, Year 2011 |
Publish date | Aug 29, 2011 (structure data deposition date) |
![]() | Sutherlin, D.P. / Bao, L. / Berry, M. / Castanedo, G. / Chuckowree, I. / Dotson, J. / Folks, A. / Friedman, L. / Goldsmith, R. / Gunzner, J. ...Sutherlin, D.P. / Bao, L. / Berry, M. / Castanedo, G. / Chuckowree, I. / Dotson, J. / Folks, A. / Friedman, L. / Goldsmith, R. / Gunzner, J. / Heffron, T. / Lesnick, J. / Lewis, C. / Mathieu, S. / Murray, J. / Nonomiya, J. / Pang, J. / Pegg, N. / Prior, W.W. / Rouge, L. / Salphati, L. / Sampath, D. / Tian, Q. / Tsui, V. / Wan, N.C. / Wang, S. / Wei, B. / Wiesmann, C. / Wu, P. / Zhu, B.Y. / Olivero, A. |
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Methods | X-ray diffraction |
Resolution | 2.788 Å |
Structure data | ![]() PDB-3tl5: |
Chemicals | ![]() ChemComp-980: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex |