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TitleGantenerumab: a novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-Beta binding and elicits cell-mediated removal of human amyloid-Beta.
Journal, issue, pagesJ. Alzheimers Dis., Vol. 28, Page 49-69, Year 2012
Publish dateJul 23, 2015 (structure data deposition date)
AuthorsBohrmann, B. / Baumann, K. / Benz, J. / Gerber, F. / Huber, W. / Knoflach, F. / Messer, J. / Oroszlan, K. / Rauchenberger, R. / Richter, W.F. ...Bohrmann, B. / Baumann, K. / Benz, J. / Gerber, F. / Huber, W. / Knoflach, F. / Messer, J. / Oroszlan, K. / Rauchenberger, R. / Richter, W.F. / Rothe, C. / Urban, M. / Bardroff, M. / Winter, M. / Nordstedt, C. / Loetscher, H.
External linksJ. Alzheimers Dis. / PubMed:21955818
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-5csz:
CRYSTAL STRUCTURE OF GANTENERUMAB FAB FRAGMENT IN COMPLEX WITH ABETA 1-11
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / ANTIBODY / ALZHEIMER / ABETA / GANTENERUMAB / GANT_ABETA_1_11 09-A

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