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TitleSynthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 133, Page 16642-16649, Year 2011
Publish dateDec 30, 2010 (structure data deposition date)
AuthorsEgli, M. / Pallan, P.S. / Allerson, C.R. / Prakash, T.P. / Berdeja, A. / Yu, J. / Lee, S. / Watt, A. / Gaus, H. / Bhat, B. ...Egli, M. / Pallan, P.S. / Allerson, C.R. / Prakash, T.P. / Berdeja, A. / Yu, J. / Lee, S. / Watt, A. / Gaus, H. / Bhat, B. / Swayze, E.E. / Seth, P.P.
External linksJ. Am. Chem. Soc. / PubMed:21919455
MethodsX-ray diffraction
Resolution1.56 Å
Structure data

PDB-3q61:
3'-Fluoro Hexitol Nucleic Acid DNA Structure
Method: X-RAY DIFFRACTION / Resolution: 1.56 Å

Chemicals

ChemComp-HOH:
WATER

KeywordsDNA / A-FORM DNA / 3'-Fluoro Hexitol Nucleic Acid / FHNA / Antisense oligonucleotides

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