タイトル | X-Ray Structures of Checkpoint Kinase 2 in Complex with Inhibitors that Target its Gatekeeper-Dependent Hydrophobic Pocket. |
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ジャーナル・号・ページ | FEBS Lett., Vol. 585, Page 3245-, Year 2011 |
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掲載日 | 2011年5月16日 (構造データの登録日) |
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著者 | Lountos, G.T. / Jobson, A.G. / Tropea, J.E. / Self, C.R. / Zhang, G. / Pommier, Y. / Shoemaker, R.H. / Waugh, D.S. |
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リンク | FEBS Lett. / PubMed:21907711 |
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手法 | X線回折 |
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解像度 | 1.89 - 2.2 Å |
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構造データ | PDB-2yiq: Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1322 手法: X-RAY DIFFRACTION / 解像度: 1.89 Å PDB-2yir: Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1352 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2yit: Structural analysis of checkpoint kinase 2 in complex with PV1162, a novel inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å |
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化合物 | ChemComp-YIQ: (E)-5-(1-(2-CARBAMIMIDOYLHYDRAZONO)ETHYL)-N-(1H-INDOL-6-YL)-1H-INDOLE-2-CARBOXAMIDE / PV-1322
ChemComp-YIR: (E)-N-(5-(2-CARBAMIMIDOYLHYDRAZONO)-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)-7-NITRO-1H-INDOLE-2-CARBOXAMIDE
ChemComp-YIT: N-{4-[(1E)-N-carbamimidoylbutanehydrazonoyl]phenyl}-5-methoxy-1H-indole-2-carboxamide / PV-1162
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / STRUCTURE-BASED DRUG DESIGN / CELL CYCLE |
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