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TitleInhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues
Journal, issue, pagesChemmedchem, Vol. 6, Page 1961-1966, Year 2011
Publish dateMay 20, 2011 (structure data deposition date)
AuthorsSzychowski, J. / Kondo, J. / Zahr, O. / Auclair, K. / Westhof, E. / Hanessian, S. / Keillor, J.W.
External linksChemmedchem / PubMed:21905229
MethodsX-ray diffraction
Resolution2.56 Å
Structure data

PDB-3s4p:
Crystal structure of the bacterial ribosomal decoding site complexed with an amphiphilic paromomycin O2''-ether analogue
Method: X-RAY DIFFRACTION / Resolution: 2.56 Å

Chemicals

ChemComp-JS6:
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-2-O-{2-[(2-phenylethyl)amino]ethyl}-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside

ChemComp-HOH:
WATER

KeywordsRNA/ANTIBIOTIC / aminoglycoside / antibiotics / ribosome / decoding site / RNA / RNA-ANTIBIOTIC complex

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